I'm on GOG, so my solution may not work on Steam.
After
patch_divinity_original_sin_2_3.0.146.969_hotfix2_(15543)_to_3.0.150.188_(15911).exe
All my saves caused a CTD
Rolling back to the previous patch fixed the issue
patch_divinity_original_sin_2_3.0.146.814_(15494)_to_3.0.146.969_hotfix2_(15543).exe
The last two patches
patch_divinity_original_sin_2_3.0.150.188_(15911)_to_3.0.150.760_(15976).exe
patch_divinity_original_sin_2_3.0.150.760_(15976)_to_3.0.150.954_(16069).exe
Loaded, but my charaxter vanished, even though companions were there, only the blue pyramid remained.
So I've rolled back to the last working patch for this playthrough. and not updating until I'm done.