I've no idea how the main plot is really going to unfold as I assume a lot of it isn't inside the alpha yet. Plus, things could change over time, if the writers are not satisfied with the story direction.
But if you're going to use something like blood stones again to unlock the story, please provide a gadget to hold them so players won't get rid of them by mistake.
(I recall some didn't finish DOS 'cos no one told them they needed to use the blood stones to unlock the story and that, I think you still needed the star stones too.)
Please protect quest items and make them unsaleable AND unusable: in DOS, there were many players who accidentally converted needed letters or whatever into spells or even sold them off or dumped them in some barrel. I truly enjoyed the extent of freedom we had but would do with a bit of concessions.
Perhaps you could even have a special inventory slot for Quest Items(if we're going to be carrying a lot:more than 6 to 8, at a time).