Did he mean in a single player playthrough, or as it in reference to multiplayer?
Both ...
There is known multiplayer workaround that will most likely work in full release.
It was confirmed that we will be able to make hirelings, wich will be basicaly another custom characters with no talking, no personality, and no story ... just there to fulfill the role you need.
And some people are SPECULATING but it was never officialy confirmed (even tho some talk in the past implyed it), that we will be able to make multiple characters at game start.