In my first playthrough of act 1, I tried nature domain on Shadowheart and it was nice, really enjoyed getting the Shillegah cantrip and spike growth and barkskin on her.
Currently though I've gone life domain and maximizing the heals, because unlike a lot of other DnD based games, the cleric spells are actually super good and I dont need spells from other classes added, and with nature domain not only are the heals stronger, but having them as innate spells frees up slots so I can carry command, blindness, silence and hold person.
I had to restart the game for the third time not too far into my second attempt after learning a certain secret thing you can do with command: drop on the nautiloid ship.