I had this issue before the original Hotfix 4. I could not load any of my saves. I tried every fix on the Larian guide and none of them helped the issue. Hotfix 4 actually solved my problem and I was able to play again. However, when Hotfix 4 was redeployed, the issue came back. I cannot load any saves from the Hotfix 4 version, nor can I load any saves from before the Hotfix version. I have tried bypassing the launcher, bypassing steam, running as admin, deleting the cache, verifying the steam files, creating an exception with Windows Defender, ensuring my drivers are up to date, running the game on a clean boot, and disabling cloud saves. I can create a new save file, new character, save and load it just fine, but everything in my current save file will not load. Any ideas?