My first playthrough I didn't really understand how to get into the city, so I figured I'd have myself arrested and sent to jail - and broke out.
Now. by doing so I missed the entire area leading up to the city, where most, if not all of the Act 3 plots are revealed, started. That was a flustercuck if ever there was one. My Tav 'knew' about plotlines I hadn't heard of yet all the damn time. At the same time, I aggro'd the folks in the building that holds the prison, so there was a villain there who never spoke a word before his end. That end came later, I couldn't beat him right away.
A scene in the previous act showed that he was important somehow, but I hadn't a clue what he was doing up there. Actually, he *did* speak to me once, when I seized the USS Enterprise he hailed me. I didn't even know what I was doing there, I just stumbled unto that thing looking for someone else entirely and thought it'd be fun. It made for a really weird conversation. I didn't realize there was a mission with an objective there. It just said 'Go back to the ship in six turns' so I killed a bunch of dudes and left.
My first playthrough was not great, let's say.