I appreciate the help, but fuck all of that. All the game needs to do is write the game-state to the HDD.
It obviously wasn't a Windows Defender issue for the first 300 hours I played and I don't have any other AV software.
I understand mods can interfere with the game files' consistency whenever an update comes out, but I shouldn't have been able to load up a game to begin if that's what causing it. I don't believe it's that either because the few I have installed are very lightweight.
And I fixed it again momentarily before something else in the game broke it. I'm about done with this garbage