[Spoiler warning]
[Fanboy Inoculation Attempt: It's a great game with sharp dialogue, but the overall story arc is a bit of a mess]
I am looking at a 'Game Over' screen right now because I refused to side with my "guardian", a mindflayer who has been deceiving me throughout the entire game, against my allies in the battle against the Illithid. There is no legitimate way that my character -- almost any good character, really -- can choose the option that Larian is effectively forcing upon us. I do not want worms eating my brain. At first I thought we were all in agreement about that. I never changed my mind and I don't think the story has given me a compelling reason to do so.
My guess is there are other people in a similar situation -- can there be a way for us to progress without being killed by a game menu?