Yes there are numerous ways to get to Moonrise without a Moonlantern or Isobel's blessing, Karlach even has an inspiration for visiting both Last Light and Moonrise without any protection.
- The simplest way is by going to the river's most southern point by the Tollhouse and just teleporting (via spells or scrolls) straight to the dock's protection auras
- Another is to equip Loviatar's mace from ACT 1 (which grants Necrotic resistance) and just running for it while chugging health potions
- Another is by using a tripple-jump ritual spell with a Strength character and jumping to the Moonrise portal. Takes like 2 turns for my Lae'zel since she is full STR with Athlete feat, so she can jump over planets.
Getting there is also quite simple because Isobel's blessing is just a mere light spell which applies to all party members, so exact same result is achieved by simply equipping a mere torch or having a Cleric (Shadowheart) cast Light on any character. The glow is wide enough to protect the entire party.
And at Moonrise is Balthazar's Moonlantern, but I prefer always taking the Drider's because I can't be bothered carrying around a silly torch and switching weapons. The pixie is the best thing ever.