If you drop off most of your spare loot before entering, it will minimize how much rearranging you will have to do afterwards (though it would be better not to have to do any). Alternately, you can bypass the guards by tossing a teleporter stone into the throne room, or for mage characters, by using the swap places special skill on one of the guards inside. You can also kill the guards by using Poison Cloud (mage spell book can be bought); cast it near, but not directly on them, to avoid a reputation drop.
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