I just whacked him a couple times with my sword...
The survivor's Curse spell can be caste repeatedly on a target fairly quickly, so even level 1 is enough to greatly reduce an opponent's resistances. That would make your other spells much more effective.
Hell Spikes does physical damage, so can not be resisted (it needs to be at level 4 or 5 for best results). Casting Blind on an opponent first can be an effective combination.