Try putting the Play CD in a drive before starting the game.
If you did the configuration file edit I mentioned in your other post about DD, you should not need the Play CD until the blessing ceremony (late in the game). Since you did a full install, you should not be prompted for a CD when choosing a character for a new game...
Try disabling AVG's real time scan, and shut down any other non-essential programs before starting the game.
Before resorting to a clean install, try deleting all of the files in the '
..\Divine Divinity\Run\Dynamic' folder (with the latest game version, if you reset the configuration files at least once after a crash when prompted, the dynamic folder should already have been cleared).
This folder is used as a cache for the game. Files are created / copied there from the save game folder when you load, and written / copied from that folder when you save a game. The files will be re-created as required the next time you start Divinity. If there was a corrupt file in that folder, deleting the files should fix the problem.
Troubleshooting Tips (& manual install procedure)
