I tended to save periodically, before entering any new areas / buildings / caves, or before anything that looked like it could be a tough fight, etc. The autosave function could certainly be tweaked, though. Maybe an autosave could be triggered by any loading screen if the game had not been saved or loaded in the previous 15 minutes, or something (possibly user defined).
Divine Divinity had 2 quicksave slots by default (that could be changed to whatever you wished, up to 99), while Beyond Divinity had 5 quicksave slots. It would be nice if D2:ED allowed additional autosave or quicksave slots (for greater flexibility if you ever wanted to revert to an earlier save), but not if that would cut into the already restrictive 20 save limit (though that isn't quite as bad since the latest Xbox update allows saves to be backed up to a USB drive).
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