The game doesn't support Crossfire / SLI, so it couldn't hurt to try disabling it.
Yeah, it's unfortunate. Wish the game was developed to support dual GPUs. The game runs fine though, still stutters on occasion, I disabled crossfire and the performance is about the same as it was before really.
With the FPS limiter thing it did make it run smoother. I'd say at times I'm getting 40 fps at best on max settings at 1920x1080 resolution, at worst 20-25 fps. Still playable, just a little annoying but not game breaking.
If the game supported dual GPUS that would be great.
As for the game not launching whenever I run the game by itself, I have no idea why it doesn't. Comrade runs it fine, the FPS limiter runs it fine and even Xfire will launch it! It's weird, but I guess it could be a bug or something with the digital versions with my current setup (Possibly W7 64 bit?).