All is worth to try out at least once
But Lockpick is good I find. But I take just enough points in Lockpck to open locket chests that have no key or I can't find the key after a thorough exploration

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And Life Leech (enchantment) I find also good, for me especially on a melee weapon because that help a bit to survive better the (most heavy) melee figthers (plus I use summon Ghost: he heal me and use fireballs at enemies!).
If I find a good Life Leech enchantment on a weapon, I don't think I take the skill Life Leech too.
Regenerate skill and enchantment Healing Aura I also find very useful ! I think I take both, the skill and search for equipment with Healing Aura on.
