I think it is probably safe to use Divine charms or level 10 enchantments. Normally I stuck to level 9 enchantments, since they has almost the same effect, but (other than healing auras) did not require a malachite gem. The two best one-handed weapons I found are listed below, both found/bought near the end of my game (finished at level 36).
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(Legendary) Disintegrating Normal Heavy Noble Sword of Doom
damage: 44-73
+39 melee damage
+29 magic damage
1 charm slot
1 enchantment slot (Increased Damage 9)
(Unique) Paladin's Well Crafted Heavy Noble Hammer of the Snake
Dropped by Ba'al in the mine; too bad I didn't go back to Broken Valley until the fjords were almost cleared.
damage: 61-75
+39 melee damage
+31 Hit Points
+3 Vitality
+4 Strength
2 charm slots
3 enchantment slots (Increased Damage 9 / Increased Magical Damage 9 / Poison 9)