Did you remember to reinstall the
patch?
When exactly does the game crash? (during or before a video or loading screen, etc)
Did you try starting a new game, at the beginning, and at the FoV section of the game? There are different cutscene videos played for each, for example, so if one works that may help narrow down the problem. However, you may want to avoid starting a character at the add-on section if you didn't finish D2:ED or had not gotten that far yet in DKS, to avoid possible spoilers.
By 'first time' do you mean it started once after you installed it, or that it worked fine on a previous computer? There is a known conflict between F-Secure Internet Security and the Securom copy protection that can cause the game not to start on subsequent attempts. It sounds like you are at least getting the game to come up, though, just not a save or new game.
[FIXED] Game won't run for the second time...[PC] Support FAQ - The Dragon Knight Saga