I was not going to reply as thought it just me being stupid so glad someone else has seen the issue!

I am still having no luck, my documents live on a network share so this could be something to do with it, however I have run lots of games before with no trouble which are looking for save games there.
I have even copied the whole Larian Studios folder from my home installation to my work machine and put it both in my network Documents and also in the local c:/Users/User/Documents folder which is not used but no good.
In fact I know it is looking at my network located docs share because if I go into the game and create a new profile, change some video and audio settings and exit, I see the new profile name appear in the playerprofiles.lsb in the network documents Larian Studios folder! But even though it can clearly see this folder, it completely ignores my previously saved profile copied from my home PC!
However, you my be right, at some point it is trying to save something to the documents folder and insists on going to a hard coded location instead of just following the path to the documents folder which it obviously knows about as I have mentioned above.
Thanks

Russ