Please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the
D:OS support tool (for the PC version). The report will contain system info, etc, as well as your saves (older saves can be deleted if size is an issue). If reloading doesn't help, or exiting the game and restarting, then there must be a problem in the save itself, so a before and after save should help Larian track down the problem.