which operating system? it aint your vid card, and so long as you have updated drivers, should be fine, only thing which differs largely from many pcs is operating system and whats running when the game is. is your operating system fully uptodate? i use winxp and i have had a few crash to desktop fatals all of which had reasons for fatal.
If you're running an original version, without the presence of any hacks, (no-cd for example) on an uptodate operating system (not winme, win95) it should work ok.
Also try to list anything common when you play/crash, ie if internet link open? firewalls or av running?
Besides defrag which probably wont have anything to do with it, but normally for installing a new game its best to defrag first, then install and patch.
Theres also running updated anti virus for obvious reasons, run scan disk, run anti-spyware, incase theres something activating in background you're not aware of..uninstalling drivers, and installing older drivers can work, check memory sticks are properly seated (especially if getting alot of random CTDs) remove the memory then reseat it. Hoover up any large deposits of dust, use a matchstick to gently scrap dust away from components, or a soft brush, make sure your fans are running when pc is on, after long periods, if crashing it could be hardware failure..due to overheating. (very rare)
I use winxp pro, on a 2.4 ghz athlon with 768meg ram, fx5600 and onboard sound from nvidia motherbouard all drivers uptodate.