Modify base resistances on player characters to a negative number.
Possible via Data\Character.txt:
new entry "HardPlayer"
[...]
data "PiercingResistance" "-20"
Modify health gains on level-up and/or per point of con.
This was hardcoded in EoCApp.exe in the beta, I believe it still is.
Modify abilities to use chance to hit.
Not sure about this one
Modify the base cooldown of abilities.
Possible via SkillData.txt:
Modify ability cooldown formula regarding primary attribute (require more int to lower cooldown, modify str and dex to do the same).
I believe this is hardcoded.
Modify AP cost of abilities.
Possible via SkillData.txt:
Modify required character level and/or skill rank of abilities.
Level requirement is changeable, skill rank I'm not sure about:
Modify talent effects (add resistance & armor penalty to glass cannon, make Bully usable on other debuff conditions, etc).
Talent effects are hardcoded, talent requirements are changeable via Data\Requirements.txt:
requirement "Escapist","!TALENT_Courageous"
Modify ability effects (include additional bonuses/penalties to attributes/skill level/AP/armor/resistances to abilities that don't currently have those effects).
Possible via the various settings in SkillData.txt.
Modify debuff states to do something completely different (replace current Blind debuff effect with penalty to hit chance and ability range, give Burning a chance to fear, give wet/chilled a movement reduction, make Frozen/Stunned/Knockdown break on damage, etc).
Possible via SkillData.txt.
Add bonuses/penalties to existing gear via crafting (craft a magic skull on your armor to add +1 con, etc).
Possible, you need to change crafting recipes in ItemCombos.xlsm and/or the item modifiers in Data/DeltaModifier.txt.
Add more random variations to crafted/blacksmith weapons in addition to existing results.
Possible, crafting recipes are in ItemCombos.xlsm.