Try the inventory button below a character portrait, before picking up anything (just at the initial landing spot on the beach).
Did you try lowering your game resolution, or switching to windowed or fake fullscreen mode?
Please email supportdos@larian.com, with a description of the problem and the report.zip file generated by the
D:OS support tool (for the PC version). The report will contain system and game information, as well as your saved games. To reduce the file size, you can delete all but one save from the zip (since the problem is consistent).
You can also check the '..\SteamApps\common\Divinity - Original Sin\Shipping' folder for any CrashDump files, and either add a couple to the report.zip, or zip them separately.