The issue Thanos was having was that saves would not show up in the load window after the game was restarted, or after switching profiles. They would load while they were shown, though.
Try browsing to the '~/Documents/Larian Studios' folder and renaming the 'Divinity Original Sin' subfolder.
This folder contains the saved games, configuration files and a level cache folder. Deleting or renaming it will get the game to recreate it on startup; playing the game from a different OSX user account would effectively do the same thing.
After that, start D:OS, create a new profile and see if you can start a new game and save/load. If that works, exit and then copy a couple saves from the renamed folder into the newly created profile's savegames folder. If that lets you load the saves, move the rest of them over (if you got far enough to that it isn't just as easy to start a new game).
If that doesn't work either, delete the new Documents D:OS folder and rename the original back again.
Are you creating a new profile to get a cleaner start with the new game, or is your previous profile not recognized?
Please email supportdos@larian.com, with your system specs, a description of the problem and one of the saves that will not load (or a new profile with just a save or two).
To get system specs you can use the 'System Report' button from the 'About This Mac' Apple menu item or the 'System Information' app (in the utilities folder).
Saves can be zipped by right clicking the folder(s) and selecting Compress, in the folder:
~/Documents/Larian Studios/Divinity Original Sin/PlayerProfiles/<ProfileName>/Savegames
It may also help to include the sampler output from the Activity Monitor:
1. Verify your Steam game cache (if applicable; there is a verification method for the App Store version, as well, see below)
2. Launch Activity Monitor
3. Start D:OS, start a new game and then save/load to get into a freeze state
4. Now Alt-Tab back to Desktop and check Activity Monitor. What do you see? How much CPU does the game consume?
5. Double click on the Divinity - Original Sin process and press 'Sample' button. Wait until Sampler is finished
6. Save sample output using 'Save' button
For the Steam version, to verifying local files, in the library, right click on Divinity Original Sin and select Properties, switch to the Local Files tab and then click on the 'Verify Integrity of Game Cache...' button.
For the GOG version, you can re-install the game, if you kept the downloaded installer (uninstall, reboot, shut down all non-essential programs, like anti-virus, make sure there is nothing left in the install folder and re-install), or try GOG's optional launcher (not sure if that will check for missing or corrupt files, or just updates).
http://www.gog.com/forum/divinity_series/divinity_original_sin_optional_launcherTo verify files with the App Store version:
Terminal
bash-3.2$ cd /Applications/
bash-3.2$ codesign -vvv Divinity\ -\ Original\ Sin.app
This takes a while, and will output some lines starting with '--prepared' or '--validated'. If everything is fine, it will end with:
Divinity - Original Sin.app: valid on disk
Divinity - Original Sin.app: satisfies its Designated Requirement