Did you run the configuration program and switch to software more?
Maybe you could pause frequently (space bar) to target enemies, etc until you get used to the faster pace?
I tried all the modes, software was no better. Even with pausing the game is unplayable. It is not really a case of getting used to the speed, more that it is too fast to follow.
One on One combat is ok with a melee weapon, but as a survivor I would like to shoot stuff from a safe distance and this is impossible. If I run away by time I try to stop and shoot Iam well off screen and if I wait for enemies to come to me then by time I see them they are already too close to shoot and run.
If I just bite the bullet and go for melee the speed just takes the entite user experience out of it and just turns the game into a case of CTRL-Clicking until either the monsters are dead or I am, with no option for strategy or running away.