If this is when using doors/hatches to switch regions, it is a known issue. There are a couple fixes, though.
In the DKS or D2:DC releases, in the Graphics options check the 'Show Advanced options' box, then scroll down to the bottom, and just above the FPS Cap slider, enable Lockstep Mode.
That isn't available in the original Ego Draconis release, but it may help to enable 'Single-Core Optimized'.
Try the
4GB Patch to increase the amount of virtual memory that the game (or any 32 bit application) can access in 64 bit versions of Windows.
One person reported that neither of those helped, but the game was fine if they disabled VSync and ran the game in XP SP3 compatibility mode (right click on a shortcut, or the divinity2.exe executable in the install folder, select Properties, and switch to the Compatibility tab).
One person reported that setting the game to run in a window fixed the problem. To do so, edit the file below in a text editor and change the one to a zero in Fullscreen="1".
C:\Users\<UserName>\AppData\Local\Divinity 2\Profile\graphicoptions.xml
You may need to set Windows Explorer to show hidden files and folders:
http://www.howtogeek.com/howto/windows-vista/show-hidden-files-and-folders-in-windows-vista/(covers Vista through Win 10)
