Have you tried with different characters, if you recruited any companions?
If you attack property or pick up any owned items around merchants, can you provoke a dialogue, or do they just drop their reputation and eventually start combat?
What about pickpocketing, and waiting for them to notice something missing?
Please email supportdos2@larian.com, with a description (or link to this topic, and your latest save (or a Dropbox or Google drive link, etc), as well as your oldest save when this started and (if available) latest save where you can still interact with merchants and shrines.
Each save is a folder in the '..\Documents\Larian Studios\Divinity Original Sin 2\PlayerProfiles\<ProfileName>\Savegames' folder. In Windows Explorer you can zip file(s) and folder(s) by right clicking on it/them and selecting 'Send To | Compressed (zipped) Folder'.