I don't suppose you have a recent backup of your My Documents folder?
Do you have
Windows shadow copies enabled, if applicable? Try right clicking the profile's savegames_patch folder, select Properties and (if available) switch to the Previous Versions tab to see if there are any previous copies.
You can try a file recovery program such as
Recuva, but it may not be able to completely restore a save, especially since the quick and auto saves are repeatedly overwritten. In general, the more you use the computer after files are deleted, the less likely they will be recoverable.
If you had cloud saves enabled, you can check in the Steam install folder, as well as My Documents, since Steam keeps a copy of the profile and saves there, which it uses when syncing online.
If you've exited out of the game Steam has probably already synced, but you can try the program
Steam Cloud File Manager Lite (
download) to check or download online saves (or delete them). You need to be logged in to the Steam client and have the game's AppID (373420 for the EE).
Other than that, you may have to revert to the previous quicksave or most recent auto or manual save.