I am having a similar issue, but with different keys. I am also left handed, and I rebound the camera movement keys plus a few others to the number pad and the arrow keys. However, every time I start up the game the default secondary binds for the camera movement keys (up, down, left, right arrows) and the hotbar (0-to-9 keys on the number pad) are being reassigned to their defaults.
I am, however, still retaining the proper primary bind key assignments I have made. For instance, the number pad 8 key (which should be moving the camera forward) will move the camera forward but will also activate whatever skill is in the 8th slot on my hotbar, because it's now assigned to two different functions in the primary and secondary bind columns.
I must go through the keybind list and clear the secondary binds for the affected keys each time I start the game. Once I clear the secondary binds for the affected keys everything works fine until I exit and restart the game.