For whatever reason DOS games (ESPECIALLY DOS 1 and DOS 1 EE) have issues with using NVidia DSR. I have a 1080p monitor, but my GTX 1080 can handle all DOS games at 4K resolution through NVidia DSR, which I use because Larian Studious decided not to implement a better form of AA, like the super-awesome Temporal AA (TAA, not TXAA) used in games like such as BF1 and Titanfall 2, etc. that can be written per-game and is not part of NVidia or AMD Library/SDK... Then again, DOS 2 is not about graphics, but gameplay.
Selecting 4K within DOS 2 results in an enlarged cursor due to lack of proper native/organic downscaling support. The only way (that I found/aware of) to get normal cursor with 4K to 1080p downscaling is by using a 3rd party tool, like HotKey Resolution Changer that can be found here -
https://funk.eu/hrc/ . With that tool you can get same 4K to 1080p DSR downscaling without experiencing the "large-cursor" side-effect.
