Just store stuff you don't need on the Lady Vengeance, make small potions into bigger ones, sell the heavy items you're not gonna wear first and keep the light stuff like jewellry for currency.
I play solo so I have half the carry weight of duo (12 ST for some armour but am also a mage with focus on Int and Wits) but rarely get over the carry weight and if I do I just send something heavy into the Store chest (you can right click sent directly from your inventory).
If I wanna store multiple items I waypoint travel there it's so easy in Dos2 with no loading screen on travel.