If you can not load the save in single player, that eliminates networking as the issues, and means the issue is due to your system (install, mods, background programs, etc), or less likely something in the save that is system dependent.
Since you reinstalled the game, that leaves the mods as a potential problem. If you and your friend use a program like DVDSig or ExactFile to scan your Mods folders, then swap the files that they create to verify, that would identify any differences.
DVDSig is tiny (
alternate download), portable and doesn't require an install, while
ExactFile has more features.
Alternately, you could use a program such as
Hash to create a list of checksum values to compare manually (slightly more work comparing, but no file swapping).
If that doesn't help, please email supportdos2@larian.com with the save (or a Dropbox or Google drive link, etc), a link to this topic and a full list of (non-Larian) mods enabled and/or the modsettings.lsx file from your profile folder.
Also check the '..\Divinity Original Sin 2\DefEd\bin' folder for the gold.log file, and if there are any 'CrashDump' files being created, zip a few together to include.