This is surprising => the locked hatch is supposed to stay locked until you got Sigurd's quest to kill Groblar and get the key by killing his bodyguards (was already locked in 1.1 or 1.2?) => before that, this quest was really buggy.
I did not kill any of Groblar's Bodyguards, and got no key. I saw the hatch and clicked on it to see if there might be some message, but it opened and I wound up in the cellar where Groblar began a dialogue about the other assassin who I had not encountered at this point.
Guano/cheese => did you talk to the Talking Tibar in the outskirts? He has a ranking quest for you.
Yes, saved him, got the quest, and have the items for him now.
Relic => have you looked at the billboard and got the info that a certain monk needs help? Did you go to him then and collect the quest?
Yes, got the info from the messageboard, talked to "Brother Raze" ( I think that is his name) several times and he keeps asking me if I have found the Holy Relic yet, but it is already in my inventory.
Spider's web => were did you find this? I can't recall a quest for it. Is it from Act 2 maybe?
This is a strange one. I picked up another quest item in one of the underground areas, it was not called a "Spider Web" at that time and I forget now what it was called (I can search all the underground areas again and find out because I flag everything that I pick up). But apparently after the last patch (not sure if it is related though) the item I picked up has changed to what looks like a greyish-purple clump of coal or rock that is now named "Spider Web".
How high are you in ranking? I need the ranking XP. please.
My current rank is 5000. The only quest that I have been able to complete after entering the town is for the Raanaar (they accepted the Raanaar Urn that was already in my inventory with no problem).
My real concern is that I have uncovered almost all of the surface area in the main game, all the surface area and 2 dungeons in the BattleField, and all the quests (except from the town) that I encountered along the way. I would rather not spend another 10 - 20 hours now to find out that I have to start Act III all over again(already restarted Act III once after the patch and getting kind of tired of doing the same things all over again).