Had a random crash earlier today, then saw that hotfix 3 went out about an hour before. Saw steam already downloaded it, and saw the updated version number on the launcher when I restarted it. Tried continuing my game, get the standard loading screen, but then it crashes after a few seconds on the loading screen. Tried loading some previous saves, same thing. Sent a copy of my save file to the friend I've been playing the game with, he tried loading it, same thing.
Haven't seen anyone else mention this on the forums/steam discussion page (which in general is a cesspool, but more active). Hope this isn't just a problem for me.