The problem I've run into the most is input lag (time before clicking/pushing buttons registers). It seems to be most apparent when dealing with inventory, but that might be something else entirely that I'm just not used to. But the big one is input not registering at all. Most of the time it has been fixable by using the panning keys, but other times not. In one instance I had to reload over and over because spacebar wasn't switching over to turn-based mode and combat was initiated before I was ready.
Back to the panning. While edge panning isn't really input, I believe it might be related. That too is fixed by using the panning keys.
