I am having a repeated issue when I have a character finish the prologue of the main story (Nautiloid in Hell). The game apparently thinks dialogue is still going on, and won't let me save. Worse, the background of the ransacked beach loads, but any objects not onscreen when the level loads fail to load, including all the companions you're supposed to recruit to your party, and all the enemies to fight. Even things like doors and the waypoints fail to load. And because you can't save, the only way to try and continue is to go back to the last autosave in the prologue, and hope that it doesn't screw up again. Unfortunately, 50% of the time, trying to reload the autosave crashes the game.