Title says it pretty well. If I try to load a save that was originally created on a PC on my MacBook Pro, the game crashes. Note that starting a new game works fine, or loading an existing Mac game works fine. The other way (Mac->PC) seems to work fine, at least prior to the recent hot fixes.
To be a little more detailed about this bug report, the game will start fine in macOS, moving past the splash screen and the initial load screen. At the first in-game menu option (as opposed to the game launcher), selecting "Continue" or "Load Campaign", then trying to pull up a save that was previously saved on a PC will cause the Mac to crash. Loading a game without the cross save "X" beside it works fine.
For the moment at least, it seems I'll need to have a separate character and storyline for the Mac. That's too bad, because the Mac side seems to support HDR whereas there the game doesn't seem to support that option on the PC/Boot Camp side.