Not sure if this is just an EA thing or a bug, but there are some issues I had with knocking out NPC's and then proceeding with the Druid Grove questline:
So I went to Nettie for a cure. Due to low rolls we ended up in combat - ok, so I knocked her unconscious. I then saved Halsin, returned to the druid cove, stopped the ritual. Everyone likes me, but Nettie is still hostile. Other druids don't care that we fight though.
I want to follow the dice and not save scum, but I would prefer if non-lethal approaches to dealing with NPC's would have some sort of story payoff. Not for every NPC, but at least ones connected with big quests.