I've mentioned a bit before about things randomly breaking, such as the falling loop that happens from time to time. I hit a much more problematic incident just now taking a party through the abandoned underground church. We snuck in through the hole made by dropping the giant brick by breaking the rope (which earlier took out two guys) and so we get that nice abandoned room which opens into a giant melee. I killed everyone in that room but they called over to the next - and during Shadowheart's turn it decided that my end turn key would simply stop - so I was in combat and couldn't use the typical save and reload to get out of it. This meant everything since my last save was wasted because I was stuck. I even tried clicking everyone else to see if they could do anything and wasted any actions I came across - I couldn't do anything to get to further turns.
Hopefully the location and scenario helps explain the sudden breakage enough to help figure out what is triggering it.