Tbh I do use player profiles to organize my save games, since I often do different playthroughs simultaneously. And I think, you can apply different mods to different profiles, if you like to try out a bit (not that I'm using mods anymore in EA since tehy broke my game after patch 4).
Yeah I am totally good with using mods, I am just giving it a week or two so they can catch up to patch 4. When I started playing, they had already announced patch 4 was coming, so I held off. Even with mods, I make a archived copy of the game folder, so if they do a patch, I delete my existing folder, and unpack the backup. That way I don't have to go through the nightmare of redownloading the entire game.