I've had numerous crashes too, and been able to mitigate many by:
Closing all programs (no discord, chrome, or antivirus running)
Run program as admin and set DPI scaling to run by application.
Bypassing the launcher. Run from the executible.
Using DirectX over Vulkan.
Some cinematic scenes prior to hotfix needed to be on low graphics.
I also did a clean install recently to help out. Hadn't done that since release day.
Curious to know if you've tried any of this or have success after doing so. I also hope to see crash fixes in the future, but I have played larian games since Divine Divinity and...well... they are known to have had crashes. Many of them patched out, but there nonetheless.