I have uninstalled the Evil Islands demo, but IIRC the size of the 64 pixel Divinity avatar was close to or a little more than size of those characters when zoomed all the way out.
Actually, fighting with the 64 pixel character wouldn't be too bad (you would be able to distinguish major moves and see differences in techniques), but loot would be fairly difficult to see without using the alt key. At this scale, higher resolution would probably need to be zoomed in a bit most of the time.