Unfortunately, the only thing Divinity uses the registry for is so that the patch can find the install path. You can check your registry and see if anything looks peculiar, though. The reg file CDV sent to someone for the manual install procedure (note the german default install path) consists of;

Quote
REGEDIT4

[HKEY_LOCAL_MACHINE\Software\CDV Software Entertainment AG\Divine Divinity]

[HKEY_LOCAL_MACHINE\Software\CDV Software Entertainment AG\Divine Divinity\English]
"target folder"="C:\\Programme\\Divine Divinity"
"group folder"="C:\\WINDOWS\\Startmenü\\Programme\\Divine Divinity"
"language"="English"
"version"="1.0"