That could be the problem, or at least a problem. Browse to that folder in Explorer and check the file size; unless the patch updates the file, it should be 385,617,662 bytes. If not, try re-extracting it from the install disk 1, ..\disc1\imagelists.rar file.
Try running ScanDisk (in Explorer right click on the drive letter, select Properties, then the Tools tab, then 'check now' under Error-checking Status). Maybe the file got cross-linked or something, though it is more likely a problem extracting it, since the same thing happened on re-installing the game.
