The files did not somehow get marked as read-only, did they? That would cause the game to crash.
Check the number of files in the saved game folder (in '..\Divine Divinity\Run\savegames'). Missing files might cause the game to crash when trying to load. A new game should have 22 files, after going to either Verdistis or the Dark Forest it should have 27, after going to both it should have 32, after getting to the wastelands it should have 37, and after getting to the Black Ring dungeon it should have 42.
