It would be really handy to be able to press a hotkey and get the map coords of the cursor (eg map number, x-coord, y-coord). This would be handy when asking for help on forums or remembering exactly where things are.
This could then feed into an Item History feature, where for each item you can see where and when you first picked it up. For keys too, it could tell you the coords of the door that the key fits (once you've used the key).
In a game with an extremely large number of quests and items - such as I hope DD2 will have - map coords can be very useful. That was my experience from BG2 anyway.
