The super drug raises poison resitance +100 and spiritual -100. Or maybe it's the other way around...
Strength potions are health + stamina.
I assume you're talking about the treasure cave. You can't get through that wall until you have all 4 treasure maps. Or maybe you can... it looks solid but you can walk right through it. I've never tried it without having the treasure maps. Later on in that cave there is a wall that must be removed by placing three orbs into a little bowl. Maybe that's the wall you're talking about?
Take the sword, kill the ghost however you can and put the sword back in the stone. Make sure you don't leave because he'll be free and will kill people.
You're done with the assassin's guild after Cybu. You won't meet the grand Cyclops.I always thought it was Janus who ordered the old Duke's death.
Go through stormfist castle first, then go to free Zandalor. I don't know if it can be done the other way around but that is how the plot is designed.