Access is faster towards the inside of a hard drive, but any recent defrag programs should be re-locating frequently accessed files and programs to the start of the drive. Even then, there is not really a huge performance difference. You may notice better performance loading a game at the start of a drive compared to the end, but you would have to be doing something very read/write intensive (large databases, etc) for that to be a significant real-world time difference.
I doubt Morbo finds the Linux distribution at the outside of the hard drive slower than the one closest to inside when doing the same types of things in all three distributions.
If you run out of space on your Windows drive/partition for the virtual swap file, that can cause crashes, and trying to save without enough space on a game drive/partition can cause an error or crash, but keeping half the drive free is very conservative.