It might work with the Divinity Universe. It's really only a game-system so far, so you could adapt it to any story. There's melee and there's guns. There's psionics (magic) and there's mutants. There's cybernetics and hi-tech equipment. It's designed with six cross-classes in mind, but has a freeform (though requirement heavy) skill tree.
Classes:
[*]Covert Operative - explosives, acrobatics and cybernetics.
[*]Matrix - super agile and dual weapons.
[*]Marine - guns so big you can wear them, walk with them or drive them.
[*]Brute - cause fear and panic, throw big things, re-animate the dead...
[*]Transcendant - manipulate the elements and evolve your body.
[*]Commander - advanced weapon tactics and convice your enemies to join you.
Just a taste 'til I can upload it tonight... <img src="/ubbthreads/images/graemlins/smile.gif" alt="" />