I had the same problem with this quest. I picked up the cremes for later use. Once you do that you break the quest. I am patched up to 1.45 and still picking up the cremes breaks the quest. I had to return to a save game several days before and replay this quest. Just using the cremes as they are on the table works. I got the message menu that the spider came over to me. This is one bug that should be fixed. Quests should have a "tree" of variables to be able to finish them.
