My chars. are level 19, I've done a ton of quests and 2 of the 3 battlefield dungeons in act 2, and the Ancient Stone Biter, that someone mentioned before, STILL kills me every time I fight it.
In huge melee fights, when all of a suggen 15 enemies show up and surround you, it can be virtually impossible to hit the potions fast enough to stay alive. And it's usually that one stupid frog or tibar or cat or whatever, that you acidentally killed one once and now they're all enemies, that pushes you over the edge.